1500: 1st black-lead pencils used in England;
1501: swift development of book printing & typography;
1503: pocket handkerchief comes into use; “Nuremberg egg” - the 1st watch;
1505: del Ferro solves a form of a cubic equation;
1506: E.Indies spice brought to Europe;
1507: manufacture of glass mirrors improved;
1510: horizontal water wheel - principle of water turbine;
1512: ban on quacks in Augsburg; Royal Navy builds double-deck ships with 70 guns, 1000 tons;
1515: 1st nationalised factories open (France weapons, tapestries);
1518: Royal College Physicians founded; E.Asian porcelain comes to Europe; spectacles for short-sighted;
1520: chocolate brought from Mexico to Spain; Henry VIII orders bowling lanes be built in Whitehall;
1521: manufacture of silk introduced to France;
1523: 1st English manual of agriculture: Fitzherbert's “Book of husbandry”; 1st marine insurance policies issued at Florence;
1524: turkeys from S.America eaten for 1st time in English court;
1525: 1st use of muskets by Spanish infantry; hops introduced to England from Artois;
1526: card game piquet 1st played;
1529: clinical bedside examination of patients introduced by Giovanni Battista da Monte; alchemy manual published;
1531: 1st complete edition of Aristotle's works published by Erasmus; the “great comet” (Halley's) arouses a wave of superstition;
1532: Chaucer's works published posthum; Machiavelli “Il Principe” written in 1513 published posthum; sugar cane Brazil;
1533: 1st lunatic asylums (without medical attention);
1535: London stock exchange;
1536: India rubber mentioned for 1st time;
1537: 1st conservatories of music founded; Fontana initiates science of ballistics; 1st map of Flanders by Mercator;
1539: 1st Christmas tree; public lottery; Magnus' map of the world;
1540: ether produced from alcohol & sulphuric acid; Servetus discovers pulmonary circulation of blood;
1542: Vesalius' anatomy; heavy taxes on drinks in Bavaria;
1543: Copernicus' heliocentric solar system challenges the embedded geocentric universe doctrine
1544: Agricola - study of physical geology; 1st herbarium published;
1546: Fracastoro's theory on epidemic diseases; Mercator states earth has a magnetic pole; 1st pharmacopoeia;
1547: Guinea pepper plant grown in England;
1550: billiards 1st played in Italy; sealing wax; 1st written reference to cricket;
1551: 1st licensing of alehouses & taverns in England;
1552: Eustachian tube; St Andrew's golf club founded;
1553: violin in its modern form begins to develop; potato from Peru;
1555: tobacco brought to Spain from America
1558: Portuguese introduce Europeans to the habit of taking snuff;
1559: position & posture of human embryo;
1560: tobacco plant imported to Europe by Jean Nicot; visiting cards used for 1st time;
1561: Lopez develops modern technique of chess playing; forerunners of hand grenades; tulips from Near East come to Europe;
1562: milled coins introduced England;
1563: 1st printing presses in Russia;
1564: horse-drawn coach introduced in England from Holland;
1565: RCP empowered to carry out human dissections; Royal Exchange founded; pencils made in England; sweet potatoes & tobacco introduced to England;
1566: 1st newspaper appears in Venice;
1568: Mercator's cylindrical projection for charts; Varolio studies anatomy of human brain; bottled beer invented;
1570: Henryson's “The moral fables of Aesop”; 1st modern atlas; Nuremberg postal service;
1572: Dutch use pigeons to carry letters during Spanish siege of Haarlem; Brahe discovers the “New Star” in the Milky Way;
1573: 1st German cane sugar refinery at Augsburg;
1575: 1st European imitations of Chinese porcelain made in Venice & Florence; pop: Paris 0.3m; London 0.18m;
1576: beginning of modern botany; Viete introduces decimal fractions;
1577: Holinshed chronicles of Britain; Drake's voyage around the world via Cape Horn;
1578: catacombs of Rome discovered;
1580: Venice imports coffee from Turkey;
1581: Galileo discovers isochronous property of pendulum; Sedan chairs in general use in England;
1582: Gregorian calendar adopted by Papal States, Spain, Portugal, France, Netherlands & Scandinavia (England: 1752);
1583: 1st known life insurance in England;
1584: Banco di Rialto founded in Venice; oldest extant wave-swept lighthouse erected at Cordouan;
1585: Stevin's law of equilibrium; 1st English travelling & standing clocks;
1589: forks used for 1st time in French courts; stocking frame & 1st knitting machine invented;
1590: 1st compound microscope; Shakespeare's “Henry VI”; coal mining begins in the Ruhr; 1st English paper mill at Dartford;
1591: skittle alleys, in use since end of 12thC, become popular in Germany;
1592: Shakespeare's “Richard III”; Pompeii ruins discovered; windmills used in Holland to drive mechanical saws;
1594: Shakespeare's “Romeo & Juliet”; 1st opera: Peri's “Dafne”; Galileo's golden rule;
1595: Shakespeare's “A Midsummer Night's Dream”; English army finally abandons bow as weapon of war; 1st heels on shoes;
1596: Shakespeare's “The Merchant of Venice”; Galileo's thermometer; Rheticus' trigonometric tables; tomatoes in England; 1st water closets for the rich;
1597: Shakespeare's “Henry IV”; 1st field hospitals & field dispensaries;
1598: Shakespeare's “Much Ado about Nothing” & “Henry V”;
1599: Shakespeare's “Julius Caesar”; Korean admiral invents iron-clad warship; Brahe's account of his discoveries & instruments;